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Details on Person SLC4A1,2,3 exchanges HCO3- for Cl-

Class:IdReaction:425482
_displayNameSLC4A1,2,3 exchanges HCO3- for Cl-
_doReleaseTRUE
_timestamp2025-08-13 18:00:34
authored[InstanceEdit:425388] Jassal, Bijay, 2009-06-04
catalystActivity[CatalystActivity:425449] solute:inorganic anion antiporter activity of SLC4A1,2,3 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:425388] Jassal, Bijay, 2009-06-04
crossReference[DatabaseIdentifier:9958952] RHEA:72364
edited[InstanceEdit:425388] Jassal, Bijay, 2009-06-04
input[SimpleEntity:188972] Cl- [extracellular region]
[SimpleEntity:111627] HCO3- [cytosol]
literatureReference[LiteratureReference:425433] Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1)
[LiteratureReference:425384] Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus
[LiteratureReference:425465] Band 3 Memphis variant II. Altered stilbene disulfonate binding and the Diego (Dia) blood group antigen are associated with the human erythrocyte band 3 mutation Pro854-->Leu
[LiteratureReference:425477] Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis
[LiteratureReference:425402] Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene
[LiteratureReference:425431] Cloning and structural characterization of a human non-erythroid band 3-like protein
[LiteratureReference:425436] Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart
modified[InstanceEdit:425499] Jassal, Bijay, 2009-06-04
[InstanceEdit:425676] Jassal, Bijay, 2009-06-05
[InstanceEdit:427553] Jassal, Bijay, 2009-06-23
[InstanceEdit:433652] Jassal, Bijay, 2009-08-24
[InstanceEdit:5657850] Jassal, Bijay, 2014-12-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9958951] Stephan, Ralf, 2025-06-26
[InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
nameSLC4A1,2,3 exchanges HCO3- for Cl-
Cl-/HCO3- exchanger transport
output[SimpleEntity:352022] Cl- [cytosol]
[SimpleEntity:425425] HCO3- [extracellular region]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:433651] He, L, 2009-08-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104092] R-HSA-425482.3
summation[Summation:425490] The proteins responsible for the exchange of Cl- with HCO3- ...
(hasEvent)[Pathway:425381] Bicarbonate transporters [Homo sapiens]
(precedingEvent)[Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785204] Update Tracker - [Reaction:425482] SLC4A1,2,3 exchanges HCO3- for Cl- - v52:[modifyText]
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