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Details on Person UniProt:Q8BKI2 Tnrc6b
| Class:Id | ReferenceGeneProduct:424270 |
|---|---|
| _chainChangeLog | chain:1-1810 added on Sat February 7 2015 |
| _displayName | UniProt:Q8BKI2 Tnrc6b |
| _timestamp | 2023-11-03 16:48:35 |
| chain | chain:1-1810 |
| checksum | 70F0A3A88CE7C7C5 |
| comment | FUNCTION Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.SUBUNIT Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Interacts with MOV10; the interaction is direct and RNA-dependent.SUBCELLULAR LOCATION Mammalian P-bodies are also known as GW bodies (GWBs).ALTERNATIVE PRODUCTS Belongs to the GW182 family. |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: Trinucleotide repeat-containing gene 6B protein |
| geneName | Tnrc6b Kiaa1093 |
| identifier | Q8BKI2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Cytoplasm Phosphoprotein Reference proteome RNA-binding RNA-mediated gene silencing Translation regulation |
| modified | [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Tnrc6b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TNR6B_MOUSE Q80TK4 |
| sequenceLength | 1810 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:424271] UniProt:Q8BKI2-1 Tnrc6b [Mus musculus] [ReferenceIsoform:424272] UniProt:Q8BKI2-2 Tnrc6b [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9621506] Tnrc6b [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8BKI2 Tnrc6b (424270)
