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Details on Person UniProt:O00337-2 SLC28A1
| Class:Id | ReferenceIsoform:423979 |
|---|---|
| _chainChangeLog | chain:1-649 added on Sat February 7 2015 |
| _displayName | UniProt:O00337-2 SLC28A1 |
| _timestamp | 2025-02-21 19:42:52 |
| chain | chain:1-649 |
| checksum | 42E952443B46B102 |
| comment | FUNCTION Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (PubMed:10455109, PubMed:14701834, PubMed:15194733, PubMed:21795683, PubMed:21998139, PubMed:30658162, PubMed:32126230, PubMed:9124315). Involved in renal nucleoside (re)absorption (PubMed:30658162).CATALYTIC ACTIVITY uridine(out) + Na(+)(out) = uridine(in) + Na(+)(in)CATALYTIC ACTIVITY thymidine(out) + Na(+)(out) = thymidine(in) + Na(+)(in)CATALYTIC ACTIVITY cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in)CATALYTIC ACTIVITY adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)ACTIVITY REGULATION Due to its high apparent affinity but slow transport, adenosine could act as a negative regulator of pyrimidine transport under some conditions.SUBCELLULAR LOCATION Expressed in kidney.PTM N-glycosylated. N-glycosylation is required for localization to the plasma membrane and the transporter activity.POLYMORPHISM All three alleles (A, B and C) have similar nucleoside transport activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Can also transport the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS).SIMILARITY Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: fullName evidence="18"Sodium/nucleoside cotransporter 1 alternativeName: fullName evidence="16"Concentrative nucleoside transporter 1 shortName evidence="16"CNT 1 shortName evidence="16"hCNT1 alternativeName: Na(+)/nucleoside cotransporter 1 alternativeName: Sodium-coupled nucleoside transporter 1 alternativeName: fullName evidence="19"Solute carrier family 28 member 1 |
| geneName | SLC28A1 CNT1 |
| identifier | O00337 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Disease variant Glycoprotein Membrane Proteomics identification Reference proteome Symport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC28A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003218] ENSEMBL:ENSG00000156222 SLC28A1 [Homo sapiens] |
| secondaryIdentifier | S28A1_HUMAN A0AV42 A8K7I2 O00335 O00336 Q5U5S6 Q5U648 Q9UEZ9 |
| sequenceLength | 649 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O00337-2 |
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No pathways have been reviewed or authored by UniProt:O00337-2 SLC28A1 (423979)
