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Details on Person UniProt:Q9NVM4-4 PRMT7
| Class:Id | ReferenceIsoform:423830 |
|---|---|
| _chainChangeLog | chain:1-692 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NVM4-4 PRMT7 |
| _timestamp | 2025-02-21 19:45:37 |
| chain | chain:1-692 |
| checksum | 9E0DB9530154231C |
| comment | FUNCTION Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.CATALYTIC ACTIVITY L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)SUBUNIT Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: Protein arginine N-methyltransferase 7 ecNumber evidence="8"2.1.1.321 alternativeName: Histone-arginine N-methyltransferase PRMT7 alternativeName: [Myelin basic protein]-arginine N-methyltransferase PRMT7 |
| geneName | PRMT7 KIAA1933 |
| identifier | Q9NVM4 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chromatin regulator Cytoplasm Differentiation Disease variant Dwarfism Intellectual disability Methylation Methyltransferase Nucleus Proteomics identification Reference proteome Repeat S-adenosyl-L-methionine Transcription Transcription regulation Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PRMT7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002800] ENSEMBL:ENSG00000132600 PRMT7 [Homo sapiens] |
| secondaryIdentifier | ANM7_HUMAN B3KPR0 B3KUG9 B4E379 Q96PV5 Q9H9L0 |
| sequenceLength | 692 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NVM4-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NVM4-4 PRMT7 (423830)
