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Details on Person UniProt:P52756-1 RBM5
| Class:Id | ReferenceIsoform:423588 |
|---|---|
| _chainChangeLog | chain:1-815 added on Fri February 6 2015 |
| _displayName | UniProt:P52756-1 RBM5 |
| _timestamp | 2025-08-15 21:33:19 |
| chain | chain:1-815 |
| checksum | AA79962D13405479 |
| comment | FUNCTION Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.SUBUNIT Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect.INTERACTION Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.SIMILARITY Belongs to the RBM5/RBM10 family.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Wrong choice of CDS. |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: RNA-binding protein 5 alternativeName: Protein G15 alternativeName: Putative tumor suppressor LUCA15 alternativeName: RNA-binding motif protein 5 alternativeName: Renal carcinoma antigen NY-REN-9 |
| geneName | RBM5 H37 LUCA15 |
| identifier | P52756 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding Spliceosome Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RBM5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992684] ENSEMBL:ENSG00000003756 RBM5 [Homo sapiens] |
| secondaryIdentifier | RBM5_HUMAN B2RA45 B4DM16 B4DMF9 B4DZ63 Q93021 Q9BU14 Q9HDA6 Q9UKY8 Q9UL24 |
| sequenceLength | 815 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P52756-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P52756-1 RBM5 (423588)
