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Details on Person UniProt:P59242-2 Cgn
| Class:Id | ReferenceIsoform:423320 |
|---|---|
| _chainChangeLog | chain:1-1191 added on Sat February 7 2015 |
| _displayName | UniProt:P59242-2 Cgn |
| _timestamp | 2023-11-03 15:25:49 |
| chain | chain:1-1191 |
| checksum | 43EA20F49AF5E7D9 |
| comment | FUNCTION Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.SUBUNIT Homodimer (By similarity). Interacts with TJP1/ZO1 and SPEF1 (By similarity).SUBCELLULAR LOCATION Localizes to the apical junction complex composed of tight and adherens junction (PubMed:15292197). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (By similarity).ALTERNATIVE PRODUCTS Lung, kidney and intestine.DOMAIN Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.SIMILARITY Belongs to the cingulin family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: fullName evidence="7"Cingulin |
| geneName | Cgn Kiaa1319 |
| identifier | P59242 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cell junction Coiled coil Phosphoprotein Reference proteome Tight junction |
| modified | [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cgn |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CING_MOUSE Q05BC4 Q69ZM0 Q6P2K0 |
| sequenceLength | 1191 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | P59242-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P59242-2 Cgn (423320)
