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Details on Person UniProt:Q5DU05-2 Cep164
| Class:Id | ReferenceIsoform:423315 |
|---|---|
| _chainChangeLog | chain:1-1446 added on Fri February 6 2015 |
| _displayName | UniProt:Q5DU05-2 Cep164 |
| _timestamp | 2023-11-03 17:52:51 |
| chain | chain:1-1446 |
| checksum | 14EB2ED0166C0FDE |
| comment | FUNCTION Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (By similarity).SUBUNIT Interacts (via N-terminus) with ATRIP. Interacts with ATM, ATR and MDC1. Interacts with XPA (via N-terminus) upon UV irradiation (By similarity). Interacts with CEP83, CCDC92, TTBK2, DVL3, NPHP3 and weakly with NPHP4 (By similarity). Interacts with DZIP1 (PubMed:23955340).SUBCELLULAR LOCATION Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis (By similarity). In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1 (By similarity). |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: fullName evidence="2"Centrosomal protein of 164 kDa shortName evidence="16"Cep164 |
| geneName | Cep164 Kiaa1052 |
| identifier | Q5DU05 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell cycle Cell division Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton DNA damage DNA repair Mitosis Nucleus Phosphoprotein Reference proteome |
| modified | [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cep164 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CE164_MOUSE Q3TYF9 Q6NZG6 Q8BQD2 Q8BSI0 |
| sequenceLength | 1446 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q5DU05-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5DU05-2 Cep164 (423315)
