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Details on Person UniProt:O75155-1 CAND2
| Class:Id | ReferenceIsoform:423311 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1236 added on Fri February 6 2015;initiator methionine:1 for 423311 removed on Fri Nov 03 2023;initiator methionine: for 423311 added on Fri Nov 03 2023;initiator methionine: for 423311 removed on Fri Aug 15 2025;initiator methionine:1 for 423311 added on Fri Aug 15 2025 |
| _displayName | UniProt:O75155-1 CAND2 |
| _timestamp | 2025-08-15 21:28:40 |
| chain | initiator methionine:1 chain:2-1236 |
| checksum | 38F43A7C1B8322A8 |
| comment | FUNCTION Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.SUBUNIT Binds TBP, CNOT3 and UBE3C.INTERACTION Expressed in epididymis (at protein level).PTM Ubiquitinated and targeted for proteasomal degradation.SIMILARITY Belongs to the CAND family. |
| created | [InstanceEdit:423310] Kanapin, AA |
| description | recommendedName: Cullin-associated NEDD8-dissociated protein 2 alternativeName: Cullin-associated and neddylation-dissociated protein 2 alternativeName: Epididymis tissue protein Li 169 alternativeName: TBP-interacting protein of 120 kDa B shortName: TBP-interacting protein 120B alternativeName: p120 CAND2 |
| geneName | CAND2 KIAA0667 TIP120B |
| identifier | O75155 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Direct protein sequencing Nucleus Proteomics identification Reference proteome Repeat Transcription Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CAND2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990572] ENSEMBL:ENSG00000144712 CAND2 [Homo sapiens] |
| secondaryIdentifier | CAND2_HUMAN B9EGM9 E9KL24 |
| sequenceLength | 1236 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75155-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75155-1 CAND2 (423311)
