Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Heterotrimeric G(s) complex dissociates

Class:Id	Reaction:422320
_displayName	Heterotrimeric G(s) complex dissociates
_doRelease	TRUE
_timestamp	2024-01-29 16:24:18
authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity	[CatalystActivity:9857004] G protein activity of G-alpha(s):GTP:G-beta:G-gamma [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:422323] May, B, 2009-05-28 03:42:30
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
input	[Complex:422322] G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:432189] Some G protein heterotrimers physically dissociate in living cells [LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells [LiteratureReference:381683] Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:381641] Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential [LiteratureReference:381700] Mechanisms of action of glucagon-like peptide 1 in the pancreas
modified	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04 [InstanceEdit:422556] D'Eustachio, P, 2009-06-02 01:00:41 [InstanceEdit:425247] May, B, 2009-06-03 [InstanceEdit:432205] May, B, 2009-08-12 [InstanceEdit:446586] May, B, 2009-11-13 [InstanceEdit:446667] May, B, 2009-11-16 [InstanceEdit:446675] May, B, 2009-11-16 [InstanceEdit:771692] May, B, 2010-05-21 [InstanceEdit:847706] May, B, 2010-05-30 [InstanceEdit:847707] May, B, 2010-05-30 [InstanceEdit:879864] May, B, 2010-06-24 [InstanceEdit:913480] May, B, 2010-07-15 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9012967] May, Bruce, 2017-07-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9860031] D'Eustachio, Peter, 2024-01-29
name	Heterotrimeric G(s) complex dissociates
output	[Complex:164358] G alpha (s):GTP [plasma membrane] [Homo sapiens] [Complex:400034] G-beta:G-gamma (candidates) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:432195] AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP [Homo sapiens] [Reaction:432188] AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex [Homo sapiens] [Reaction:381706] GLP1R:GLP1 activates G(s) [Homo sapiens] [Reaction:381612] GLP1R binds GLP1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2010-06-15
reviewed	[InstanceEdit:879857] Beitz, E, 2010-06-24 [InstanceEdit:913479] Calamita, G, 2010-07-15 [InstanceEdit:9860030] D'Eustachio, Peter, 2024-01-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104158] R-HSA-422320.4
structureModified	[InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29
summation	[Summation:422321] The binding of GTP by G(s) alpha causes the heterotrimeric G...
(hasEvent)	[Pathway:381676] Glucagon-like Peptide-1 (GLP1) regulates insulin secretion [Homo sapiens] [Pathway:432040] Vasopressin regulates renal water homeostasis via Aquaporins [Homo sapiens]
(precedingEvent)	[Reaction:163617] G alpha (s) activates adenylate cyclase [Homo sapiens] [Reaction:381704] G(s):GTP activates Adenylyl cyclase [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:9012902] G alpha(s) activates ADCY6 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791346] Update Tracker - [Reaction:422320] Heterotrimeric G(s) complex dissociates - v31:[modifyText] [_UpdateTracker:9791443] Update Tracker - [Reaction:422320] Heterotrimeric G(s) complex dissociates - v30:[addLiteratureReference] [_UpdateTracker:9864233] Update Tracker - [Reaction:422320] Heterotrimeric G(s) complex dissociates - v88:[addCatalystActivity]
[Change default viewing format]

No pathways have been reviewed or authored by Heterotrimeric G(s) complex dissociates (422320)