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Details on Person Expression of Preproghrelin

Class:Id	BlackBoxEvent:422088
_displayName	Expression of Preproghrelin
_doRelease	TRUE
_timestamp	2018-10-31 14:31:01
authored	[InstanceEdit:426529] May, B, 2009-06-10
compartment	[Compartment:7660] nucleoplasm [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:422063] May, B, 2009-05-25 21:41:39
edited	[InstanceEdit:426529] May, B, 2009-06-10
input	[EntityWithAccessionedSequence:5652756] GHRL gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:538960] Ghrelin is a growth-hormone-releasing acylated peptide from stomach [LiteratureReference:538974] The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans [LiteratureReference:434552] Characterization and regulation of the rat and human ghrelin promoters [LiteratureReference:434550] Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene [LiteratureReference:434459] KLF4 positively regulates human ghrelin expression [LiteratureReference:422105] Ghrelin fluctuation, what determines its production? [LiteratureReference:422095] Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle
modified	[InstanceEdit:426535] May, B, 2009-06-16 [InstanceEdit:434279] May, B, 2009-08-27 [InstanceEdit:434419] May, B, 2009-08-29 [InstanceEdit:434458] May, B, 2009-08-29 [InstanceEdit:434557] May, B, 2009-08-31 [InstanceEdit:538922] May, B, 2010-03-09 [InstanceEdit:640727] May, B, 2010-04-30 [InstanceEdit:5652757] May, Bruce, 2014-11-29 [InstanceEdit:8931584] May, Bruce, 2016-07-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627000] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of Preproghrelin
output	[DefinedSet:422026] Preproghrelin and prepro-des-Gln14-ghrelin [endoplasmic reticulum lumen] [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:434462] Positive gene expression regulation by 'KLF4 [nucleoplasm]' [NegativeGeneExpressionRegulation:8931572] Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]'
regulationReference	[RegulationReference:9641730] Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]' Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors [RegulationReference:9641982] Positive gene expression regulation by 'KLF4 [nucleoplasm]' KLF4 positively regulates human ghrelin expression
releaseDate	2009-09-30
reviewed	[InstanceEdit:434405] Zhang, Weizhen, 2009-08-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105312] R-HSA-422088.7
summation	[Summation:422049] The ghrelin gene is transcribed and spliced to yield two var... [Summation:8933559] As inferred from rat homologues, Urocortin (UCN) binds the C...
(hasEvent)	[Pathway:422085] Synthesis, secretion, and deacylation of Ghrelin [Homo sapiens]
(precedingEvent)	[Reaction:422051] Cleavage of the signal peptide of Preproghrelin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776059] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v78:[addSummation] [_UpdateTracker:9782940] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v58:[addRegulator] [_UpdateTracker:9785434] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v52:[addInput] [_UpdateTracker:9790545] Update Tracker - [BlackBoxEvent:422088] Expression of Preproghrelin - v33:[addLiteratureReference]
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No pathways have been reviewed or authored by Expression of Preproghrelin (422088)