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Details on Person Ghrelin O-acyltransferase decanoylates Proghrelin

Class:Id	Reaction:422017
_displayName	Ghrelin O-acyltransferase decanoylates Proghrelin
_doRelease	TRUE
_timestamp	2014-02-04 22:50:47
authored	[InstanceEdit:426529] May, B, 2009-06-10
catalystActivity	[CatalystActivity:422079] acyltransferase activity, transferring groups other than amino-acyl groups of MBOAT4 [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:422063] May, B, 2009-05-25 21:41:39
edited	[InstanceEdit:426529] May, B, 2009-06-10
input	[EntityWithAccessionedSequence:422102] GHRL-1(24-117) [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:422019] DECA [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:422087] Ghrelin octanoylation mediated by an orphan lipid transferase [LiteratureReference:434436] Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid [LiteratureReference:434449] Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing [LiteratureReference:422105] Ghrelin fluctuation, what determines its production? [LiteratureReference:422095] Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle
modified	[InstanceEdit:426532] May, B, 2009-06-16 [InstanceEdit:434276] May, B, 2009-08-27 [InstanceEdit:434413] May, B, 2009-08-29 [InstanceEdit:434450] May, B, 2009-08-29 [InstanceEdit:538922] May, B, 2010-03-09 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ghrelin O-acyltransferase decanoylates Proghrelin
output	[EntityWithAccessionedSequence:422031] DecS-GHRL-1(24-117) [endoplasmic reticulum lumen] [Homo sapiens]
precedingEvent	[Reaction:422051] Cleavage of the signal peptide of Preproghrelin [Homo sapiens] [BlackBoxEvent:422088] Expression of Preproghrelin [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:434405] Zhang, Weizhen, 2009-08-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104955] R-HSA-422017.2
summation	[Summation:422081] Proghrelin is decanoylated by ghrelin O-acyltransferase (GOA...
(hasEvent)	[Pathway:422085] Synthesis, secretion, and deacylation of Ghrelin [Homo sapiens]
(precedingEvent)	[Reaction:422021] PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790498] Update Tracker - [Reaction:422017] Ghrelin O-acyltransferase decanoylates Proghrelin - v33:[removeLiteratureReference]
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No pathways have been reviewed or authored by Ghrelin O-acyltransferase decanoylates Proghrelin (422017)