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Details on Person Class 2 myosins are a set of protein complexes that bind act...
| Class:Id | Summation:420902 |
|---|---|
| _displayName | Class 2 myosins are a set of protein complexes that bind act... |
| _timestamp | 2009-05-14 14:47:50 |
| created | [InstanceEdit:420898] Jupe, S, 2009-05-14 14:47:47 |
| literatureReference | [LiteratureReference:420901] Myosin II isoforms in smooth muscle: heterogeneity and function [LiteratureReference:419187] Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells |
| text | Class 2 myosins are a set of protein complexes that bind actin and hydrolyse ATP, acting as molecular motors. They consist of two myosin heavy chains , two essential light chains and two regulatory light chains (MRLCs). Smooth muscle and non-muscle myosin isoforms are a subset of Class 2 myosin complexes. The nomenclature for isoforms is misleading, as non-muscle isoforms can be found in smooth muscle. The 4 smooth muscle isoforms all have heavy chains encoded by MYH11. The non-muscle isoforms have heavy chains encoded by MYH9, MYH10 or MYH14 (NMHC-IIA, B and C). The essential light chain (LC17) common to smooth and non-muscle isoforms is encoded by MYL6. The regulatory light chain (LC20) is encoded by either MYL9, giving a slightly more basic protein that is referred to as the smooth muscle LC20 isoform, and MRLC2, giving a more acidic isoform referred to as the non-muscle LC20 isoform. Class 2 myosins play a crucial role in a variety of cellular processes, including cell migration, polarity formation, and cytokinesis. |
| (summation) | [Complex:419194] Smooth muscle/non-muscle myosin II [cytosol] [Homo sapiens] [Complex:425279] Smooth muscle/non-muscle myosin II [cytosol] [Gallus gallus] [Complex:5668934] p-T19-MRLC-Smooth muscle/non-muscle myosin II [cytosol] [Homo sapiens] [Complex:5671938] Smooth muscle/non-muscle myosin II [cytosol] [Bos taurus] |
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