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Details on Person FANCI is monoubiquitinated on lysine 523 in an FA core-com...

Class:Id	Summation:420760
_displayName	FANCI is monoubiquitinated on lysine 523 in an FA core-com...
_timestamp	2009-06-09 13:59:44
created	[InstanceEdit:420758] Matthews, L, 2009-05-13 16:02:38
literatureReference	[LiteratureReference:265816] Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair [LiteratureReference:420772] FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway [LiteratureReference:265872] FANCI is a second monoubiquitinated member of the Fanconi anemia pathway
modified	[InstanceEdit:420778] Matthews, L, 2009-05-13 16:03:17 [InstanceEdit:421849] Matthews, L, 2009-05-21 22:12:01 [InstanceEdit:422560] Matthews, L, 2009-06-02 03:20:41 [InstanceEdit:425932] Matthews, L, 2009-06-09
text	FANCI is monoubiquitinated on lysine 523 in an FA core-complex-dependent manner (Sims et al., 2007; Smogorzewska et al. 2007). FANCD2 and FANCI are mutually dependent on each other for their respective monoubiquitination. However, multiple phosphorylation of FANCI but not monoubiquitination is crucial for FANCD2 activation following DNA damage (Ishiai et al., 2008).
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