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Details on Person GABAB heterodimeric receptor binds GABA

Class:Id	Reaction:420688
_displayName	GABAB heterodimeric receptor binds GABA
_doRelease	TRUE
_timestamp	2019-12-16 11:47:22
authored	[InstanceEdit:420735] Jassal, Bijay, 2009-05-13
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:420735] Jassal, Bijay, 2009-05-13
edited	[InstanceEdit:420735] Jassal, Bijay, 2009-05-13
input	[SimpleEntity:352003] GABA [extracellular region] [Complex:420748] GABBR1:GABBR2 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:420731] Heterodimerization is required for the formation of a functional GABA(B) receptor [LiteratureReference:420692] Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels
modified	[InstanceEdit:420852] Jassal, Bijay, 2009-05-14 [InstanceEdit:422124] Jassal, Bijay, 2009-05-26 [InstanceEdit:422382] Jassal, Bijay, 2009-05-29 [InstanceEdit:532503] Jupe, S, 2010-03-01 [InstanceEdit:997362] Mahajan, SS, 2010-11-08 [InstanceEdit:1013818] Mahajan, SS, 2010-11-12 [InstanceEdit:1034508] Jupe, S, 2010-11-18 [InstanceEdit:9670776] Jassal, Bijay, 2019-12-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GABAB heterodimeric receptor binds GABA
output	[Complex:420698] GABBR1:GABBR2:GABA [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:888589] Release of GABA at the synapse [Homo sapiens] [Reaction:917744] GABA loaded synaptic vesicle Docking and Priming [Homo sapiens] [Reaction:9670745] LTCC pentamer transports Ca2+ from extracellular region to cytosol in neurons [Homo sapiens]
releaseDate	2009-06-24
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104281] R-HSA-420688.3
summation	[Summation:420736] Gamma-aminobutyric acid (GABA) is the chief inhibitory neuro...
(hasEvent)	[Pathway:420499] Class C/3 (Metabotropic glutamate/pheromone receptors) [Homo sapiens] [Pathway:977444] GABA B receptor activation [Homo sapiens]
(precedingEvent)	[Reaction:749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi [Homo sapiens] [Reaction:1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels [Homo sapiens] [Reaction:1013013] Association of GABA B receptor with G protein beta-gamma subunits [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780212] Update Tracker - [Reaction:420688] GABAB heterodimeric receptor binds GABA - v63:[modifyText]
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