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Details on Person Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions

Class:Id	Reaction:420661
_displayName	Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions
_doRelease	TRUE
_timestamp	2022-08-10 03:37:59
authored	[InstanceEdit:421262] Matthews, L, 2009-05-15 19:26:33
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:420662] Matthews, L, 2009-05-12 19:53:03
edited	[InstanceEdit:421400] Matthews, L, 2009-05-18 16:34:30
input	[EntityWithAccessionedSequence:420009] CRB3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:419969] MPP5 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:420011] PATJ [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:421254] hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells [LiteratureReference:421242] PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells
modified	[InstanceEdit:420667] Matthews, L, 2009-05-12 19:53:17 [InstanceEdit:421233] Matthews, L, 2009-05-17 21:12:01 [InstanceEdit:421546] Matthews, L, 2009-05-18 22:48:49 [InstanceEdit:421973] Matthews, L, 2009-05-22 17:07:30 [InstanceEdit:425526] Matthews, L, 2009-06-04 [InstanceEdit:433736] Matthews, L, 2009-08-25 [InstanceEdit:434155] Matthews, L, 2009-08-26 [InstanceEdit:446751] Matthews, L, 2009-11-17 [InstanceEdit:9710553] Shamovsky, Veronica, 2021-01-05 [InstanceEdit:9716571] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9736375] Shamovsky, Veronica, 2021-07-07 [InstanceEdit:9751153] Shamovsky, Veronica, 2021-08-18 [InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9768017] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9796138] Shamovsky, Veronica, 2022-08-05 [InstanceEdit:9796512] Shamovsky, Veronica, 2022-08-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions
output	[Complex:420663] CRB3:PALS1:PATJ complex [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeRegulation:9766196] Negative regulation by 'MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]'
regulationReference	[RegulationReference:9766201] Negative regulation by 'MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]' Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein
releaseDate	2009-09-30
reviewed	[InstanceEdit:434154] Ebnet, K, 2009-08-26 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105223] R-HSA-420661.6
summation	[Summation:421227] The CRB3:PALS1:PATJ complex is the second major cell polarit...
(hasEvent)	[Pathway:420029] Tight junction interactions [Homo sapiens] [Pathway:9705677] SARS-CoV-2 targets PDZ proteins in cell-cell junction [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774963] Update Tracker - [Reaction:420661] Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions - v80:[addRegulator, modifyText] [_UpdateTracker:9776432] Update Tracker - [Reaction:420661] Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions - v76:[modifyText] [_UpdateTracker:9782327] Update Tracker - [Reaction:420661] Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions - v59:[modifyText] [_UpdateTracker:9789670] Update Tracker - [Reaction:420661] Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions - v37:[modifyText] [_UpdateTracker:9791350] Update Tracker - [Reaction:420661] Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions - v31:[modifyText]
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