Query author contributions in Reactome
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Details on Person Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroi...
| Class:Id | Summation:420477 |
|---|---|
| _displayName | Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroi... |
| _timestamp | 2009-05-12 14:19:25 |
| created | [InstanceEdit:420459] Jassal, Bijay, 2009-05-12 |
| text | Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroid hormone-related protein (PTHrP) (Suva LJ et al, 1987) and tuberoinfundibular peptide of thirty-nine residues (TIP39) (Hansen IA et al, 2002; Della Penna K et al, 2003) are endogenous ligands for the parathyroid hormone 1 and 2 receptors. These peptide hormones play a key role in controlling blood Ca(2+) concentration and endochondral bone formation. PTH1 is the classical PTH receptor 1 (Schipani E et al, 1993; Schneider H et al, 1993) and is expressed in high levels in bone and kidney. It regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. PTH receptor 2 (Usdin TB et al, 1995) is most abundant in brain and testes and potently activated by PTH. The activity of these receptors is mediated by G proteins which activate adenylyl cyclase (Schneider H et al, 1994; Offermanns S et al, 1996; Behar V et al, 1996). |
| (summation) | [Reaction:420489] Parathyroid hormone receptor can bind parathyroid hormone [Homo sapiens] |
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No pathways have been reviewed or authored by Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroi... (420477)
