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Details on Person PALB2 [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:419548
_displayName	PALB2 [nucleoplasm]
_timestamp	2010-12-02 14:45:50
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:419550] Matthews, L, 2009-05-02 17:28:34
endCoordinate	1186
modified	[InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:3448660] Wu, G, 2013-05-16
name	PALB2 Partner and localizer of BRCA2 PALB2_HUMAN
referenceEntity	[ReferenceGeneProduct:241569] UniProt:Q86YC2 PALB2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1106797] R-HSA-419548.1
startCoordinate	1
(hasComponent)	[Complex:517917] BRCA1:BRCA2:PALB2 [nucleoplasm] [Homo sapiens] [Complex:5685655] BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Homo sapiens]
(input)	[Reaction:447346] Formation of the BRCA1-PALB2-BRCA2 complex [Reaction:5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51 [Homo sapiens] [FailedReaction:9701199] Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding [Homo sapiens] [FailedReaction:9709601] Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9704404] loss_of_function of PALB2 mutants (BRCA2/RAD51/RAD51C binding) [nucleoplasm] [EntityFunctionalStatus:9704407] loss_of_function of PALB2 mutants (BRCA1 binding) [nucleoplasm]
(output)	[Reaction:5686410] BLM mediates dissolution of double Holliday junction [Homo sapiens] [BlackBoxEvent:5686469] Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 [Homo sapiens] [BlackBoxEvent:5686483] Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [Homo sapiens] [Reaction:5693589] D-loop dissociation and strand annealing [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9880267] Update Tracker - [EntityWithAccessionedSequence:419548] PALB2 [nucleoplasm] - v44:[addEndCoordinate, addStartCoordinate]
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No pathways have been reviewed or authored by PALB2 [nucleoplasm] (419548)