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Details on Person The FANCD2 and FANCI proteins are monoubiquitinated by th...
| Class:Id | Summation:419519 |
|---|---|
| _displayName | The FANCD2 and FANCI proteins are monoubiquitinated by th... |
| _timestamp | 2009-05-21 22:13:26 |
| created | [InstanceEdit:419521] Matthews, L, 2009-05-02 17:27:45 |
| literatureReference | [LiteratureReference:265872] FANCI is a second monoubiquitinated member of the Fanconi anemia pathway [LiteratureReference:419536] A novel ubiquitin ligase is deficient in Fanconi anemia [LiteratureReference:265816] Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair |
| modified | [InstanceEdit:420758] Matthews, L, 2009-05-13 16:02:38 [InstanceEdit:420797] Matthews, L, 2009-05-13 18:53:00 [InstanceEdit:421849] Matthews, L, 2009-05-21 22:12:01 |
| text | The FANCD2 and FANCI proteins are monoubiquitinated by the Fanconi anemia ubiquitin ligase complex (Sims et al., 2007 (?), Smogorzewska et al., 2007)(Meetei et al., 2003) (ref?). The ubiquitination of each is important for the maintenance of ubiquitin on the other suggesting that a dual ubiquitin-locking mechanism is required for FANCD2 and FANCI function (Smogorzewska et al., 2007). The monoubiquitinated FANCD2 and FANCI appears to coordinately bind to chromatin (ref). |
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No pathways have been reviewed or authored by The FANCD2 and FANCI proteins are monoubiquitinated by th... (419519)
