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Details on Person 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate

Class:Id	Reaction:419254
_displayName	5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
_doRelease	TRUE
_timestamp	2016-11-10 00:57:07
authored	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
catalystActivity	[CatalystActivity:419247] phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419263] D'Eustachio, P, 2009-04-29 19:22:36
edited	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
input	[SimpleEntity:111409] AICAR [cytosol] [SimpleEntity:419151] 10-formyl-THF [cytosol]
literatureReference	[LiteratureReference:419249] On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver [LiteratureReference:419252] Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
modified	[InstanceEdit:419265] D'Eustachio, P, 2009-04-29 19:22:50 [InstanceEdit:1660613] D'Eustachio, P, 2011-10-13 [InstanceEdit:1667320] D'Eustachio, P, 2011-10-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
output	[SimpleEntity:111427] FAICAR [cytosol] [SimpleEntity:111355] THF [cytosol]
precedingEvent	[Reaction:419255] 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate [Gallus gallus] [Reaction:419223] 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate [Gallus gallus]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016277] R-GGA-419254.3
summation	[Summation:419251] The phosphoribosylaminoimidazolecarboxamide formyltransferas...
(hasEvent)	[Pathway:419140] De novo synthesis of IMP [Gallus gallus]
(precedingEvent)	[Reaction:419253] 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O [Gallus gallus]
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No pathways have been reviewed or authored by 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (419254)