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Details on Person 5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)

Class:Id	Reaction:419214
_displayName	5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
_doRelease	TRUE
_timestamp	2016-11-10 00:56:39
authored	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
catalystActivity	[CatalystActivity:419225] phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419211] D'Eustachio, P, 2009-04-29 14:44:31
edited	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
input	[SimpleEntity:111370] AIR [cytosol] [SimpleEntity:113528] CO2 [cytosol]
literatureReference	[LiteratureReference:111324] De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli [LiteratureReference:419216] Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms [LiteratureReference:419222] Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis
modified	[InstanceEdit:419227] D'Eustachio, P, 2009-04-29 14:44:47 [InstanceEdit:419263] D'Eustachio, P, 2009-04-29 19:22:36 [InstanceEdit:1660613] D'Eustachio, P, 2011-10-13 [InstanceEdit:1667320] D'Eustachio, P, 2011-10-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
output	[SimpleEntity:111395] CAIR [cytosol]
precedingEvent	[Reaction:419157] 5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate [Gallus gallus] [Reaction:419144] 5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate [Gallus gallus]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016466] R-GGA-419214.3
summation	[Summation:419212] The phosphoribosylaminoimidazole carboxylase activity of cyt...
(hasEvent)	[Pathway:419140] De novo synthesis of IMP [Gallus gallus]
(precedingEvent)	[Reaction:419223] 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate [Gallus gallus]
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No pathways have been reviewed or authored by 5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) (419214)