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Details on Person The phosphoribosylaminoimidazolesuccinocarboxamide synthase ...
| Class:Id | Summation:419206 |
|---|---|
| _displayName | The phosphoribosylaminoimidazolesuccinocarboxamide synthase ... |
| _timestamp | 2009-04-29 14:44:52 |
| created | [InstanceEdit:419211] D'Eustachio, P, 2009-04-29 14:44:31 |
| modified | [InstanceEdit:419227] D'Eustachio, P, 2009-04-29 14:44:47 |
| text | The phosphoribosylaminoimidazolesuccinocarboxamide synthase activity of cytosolic PAICS (multifunctional protein ADE2) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR), L-aspartate, and ATP to form 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR), ADP, and orthophosphate. Chicken PAICS protein has been purified and its catalytic properties analyzed in vitro (Firestine and Davisson 1994). The native chicken protein behaves as a large multimer on gel filtration; it is inferred to be a octamer by analogy to the human protein (Li et al. 2007). The subcellular location of the chicken enzyme is inferred from that of its better-characterized mammalian counterparts. |
| (summation) | [Reaction:419223] 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate [Gallus gallus] |
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