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Details on Person Myosin regulatory light chain phosphorylation by ROCK

Class:IdReaction:419197
_displayNameMyosin regulatory light chain phosphorylation by ROCK
_doReleaseTRUE
_timestamp2015-01-28 18:30:22
authored[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity[CatalystActivity:419084] protein serine/threonine kinase activity of Activated ROCK:RhoA/B/C:GTP [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:419198] Jupe, S, 2009-04-29 13:41:48
edited[InstanceEdit:421726] Jupe, S, 2009-05-20 09:50:28
inferredFrom
input[Complex:419194] Smooth muscle/non-muscle myosin II [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:419192] Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
[LiteratureReference:419187] Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells
[LiteratureReference:435413] Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells
[LiteratureReference:5668847] Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase
[LiteratureReference:5668846] Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin
modified[InstanceEdit:419200] Jupe, S, 2009-04-29 14:23:44
[InstanceEdit:419586] Jupe, S, 2009-05-05 12:11:49
[InstanceEdit:419881] Jupe, S, 2009-05-07 09:48:51
[InstanceEdit:421709] Jupe, S, 2009-05-19 14:28:17
[InstanceEdit:421726] Jupe, S, 2009-05-20 09:50:28
[InstanceEdit:422117] Garapati, P V, 2009-05-26 10:26:49
[InstanceEdit:422119] Garapati, P V, 2009-05-26 10:52:13
[InstanceEdit:422120] Garapati, P V, 2009-05-26 12:04:08
[InstanceEdit:422470] Garapati, P V, 2009-05-31 15:13:55
[InstanceEdit:425207] Jupe, S, 2009-06-03
[InstanceEdit:425227] Garapati, P V, 2009-06-03
[InstanceEdit:425944] Garapati, P V, 2009-06-09
[InstanceEdit:427482] Jupe, S, 2009-06-22
[InstanceEdit:434703] Matthews, L, 2009-09-02
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5668850] Orlic-Milacic, Marija, 2015-01-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMyosin regulatory light chain phosphorylation by ROCK
output[Complex:419195] p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5668845] Orlic-Milacic, Marija, 2015-01-28
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104227] R-HSA-419197.2
summation[Summation:419189] Nonmuscle myosin II (NMM2) is an actin-based motor protein t...
(hasEvent)[Pathway:416572] Sema4D induced cell migration and growth-cone collapse [Homo sapiens]
[Pathway:419233] Cytoskeletal regulation [Homo sapiens]
[Pathway:5627117] RHO GTPases Activate ROCKs [Homo sapiens]
(precedingEvent)[Reaction:419232] Myosin phosphatase dephosphorylates myosin regulatory light chain [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785050] Update Tracker - [Reaction:419197] Myosin regulatory light chain phosphorylation by ROCK - v52:[addLiteratureReference, modifyText]
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