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Details on Person 5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate

Class:Id	Reaction:419145
_displayName	5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
_doRelease	TRUE
_timestamp	2016-11-10 00:56:36
authored	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
catalystActivity	[CatalystActivity:419132] phosphoribosylglycinamide formyltransferase activity of GART [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:419136] D'Eustachio, P, 2009-04-28 21:22:12
edited	[InstanceEdit:419262] D'Eustachio, P, 2009-04-29 19:20:17
input	[SimpleEntity:111338] PRGA [cytosol] [SimpleEntity:419151] 10-formyl-THF [cytosol]
literatureReference	[LiteratureReference:111330] A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis [LiteratureReference:419150] Cloning and expression of avian glutamine phosphoribosylpyrophosphate amidotransferase. Conservation of a bacterial propeptide sequence supports a role for posttranslational processing
modified	[InstanceEdit:419263] D'Eustachio, P, 2009-04-29 19:22:36 [InstanceEdit:1660613] D'Eustachio, P, 2011-10-13 [InstanceEdit:1667320] D'Eustachio, P, 2011-10-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
output	[SimpleEntity:111354] N-Formyl-GAR [cytosol] [SimpleEntity:111355] THF [cytosol]
precedingEvent	[Reaction:419153] 5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate [Gallus gallus] [Reaction:419152] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate [Gallus gallus]
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016639] R-GGA-419145.3
summation	[Summation:419138] The phosphoribosylglycinamide formyltransferase activity of ...
(hasEvent)	[Pathway:419140] De novo synthesis of IMP [Gallus gallus]
(precedingEvent)	[Reaction:419144] 5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate [Gallus gallus]
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No pathways have been reviewed or authored by 5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate (419145)