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Details on Person LIM kinase phosphorylation by ROCK

Class:IdReaction:419087
_displayNameLIM kinase phosphorylation by ROCK
_doReleaseTRUE
_timestamp2015-02-12 20:00:44
authored[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity[CatalystActivity:419084] protein serine/threonine kinase activity of Activated ROCK:RhoA/B/C:GTP [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:419086] Jupe, S, 2009-04-28 12:55:15
edited[InstanceEdit:419086] Jupe, S, 2009-04-28 12:55:15
inferredFrom
input[CandidateSet:419708] LIM Kinases [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:420679] Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
[LiteratureReference:420676] Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase
[LiteratureReference:434919] Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets
modified[InstanceEdit:419661] Jupe, S, 2009-05-05 12:54:28
[InstanceEdit:419712] Jupe, S, 2009-05-06 13:22:25
[InstanceEdit:419880] Jupe, S, 2009-05-07 09:48:03
[InstanceEdit:420652] Jupe, S, 2009-05-12 17:12:27
[InstanceEdit:420681] Jupe, S, 2009-05-13 13:41:56
[InstanceEdit:421732] Jupe, S, 2009-05-20 11:58:07
[InstanceEdit:421739] Jupe, S, 2009-05-20 12:45:37
[InstanceEdit:422117] Garapati, P V, 2009-05-26 10:26:49
[InstanceEdit:422119] Garapati, P V, 2009-05-26 10:52:13
[InstanceEdit:422120] Garapati, P V, 2009-05-26 12:04:08
[InstanceEdit:422469] Garapati, P V, 2009-05-31 15:11:59
[InstanceEdit:425200] Garapati, Phani Vijay, 2009-06-03
[InstanceEdit:425944] Garapati, P V, 2009-06-09
[InstanceEdit:427481] Jupe, S, 2009-06-22
[InstanceEdit:434703] Matthews, L, 2009-09-02
[InstanceEdit:631250] Jupe, S, 2010-04-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5668845] Orlic-Milacic, Marija, 2015-01-28
[InstanceEdit:5674554] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLIM kinase phosphorylation by ROCK
output[CandidateSet:419709] p-LIMK [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2009-09-30
reviewed[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105857] R-HSA-419087.2
summation[Summation:419713] LIM kinases are serine protein kinases with a unique combina...
(hasEvent)[Pathway:416572] Sema4D induced cell migration and growth-cone collapse [Homo sapiens]
[Pathway:419233] Cytoskeletal regulation [Homo sapiens]
[Pathway:5627117] RHO GTPases Activate ROCKs [Homo sapiens]
(precedingEvent)[Reaction:419736] LIM kinase inactivation of ADF/cofilin-1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785142] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v52:[addLiteratureReference, modifyText]
[_UpdateTracker:9785854] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v51:[modifyText]
[_UpdateTracker:9786850] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v47:[modifyText]
[_UpdateTracker:9790648] Update Tracker - [Reaction:419087] LIM kinase phosphorylation by ROCK - v33:[addLiteratureReference]
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No pathways have been reviewed or authored by LIM kinase phosphorylation by ROCK (419087)
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