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Details on Person Platelets circulating in blood are discoid, but on activatio...
| Class:Id | Summation:419054 |
|---|---|
| _displayName | Platelets circulating in blood are discoid, but on activatio... |
| _timestamp | 2009-09-02 15:45:38 |
| created | [InstanceEdit:419048] Jupe, S, 2009-04-28 12:51:40 |
| literatureReference | [LiteratureReference:419053] Applications for ROCK kinase inhibition [LiteratureReference:434752] Platelet function: assessment, diagnosis, and treatment. Ed. Martin Quinn, Desmond Fitzgerald. Humana Press, 2005. ISBN 1588292444, 9781588292445 |
| modified | [InstanceEdit:419690] Jupe, S, 2009-05-05 16:59:26 [InstanceEdit:434753] Jupe, S, 2009-09-02 |
| text | Platelets circulating in blood are discoid, but on activation they undergo a reproducible series of morphological changes: first they become rounded, then they project filopodia, spread and finally contract. Actin reorganisation precedes these changes. Actin polymerization and reorganisaion is regulated by a complex set of biochemical and interaction events. ROCK-mediated pathways lead to increased actin-myosin contractility. Active GTP-bound Rho associates with ROCK and increases the phosphorylation of numerous substrate proteins, including the myosin-binding subunit of myosin light chain (MLC) phosphatase, resulting in the inhibition of MLC dephosphorylation. Direct phosphorylation of the MLC by ROCK has also been reported. Increased MLC phosphorylation promotes binding to filamentous actin. ROCK phosphorylation of LIMK1 and LIMK2 increases their specific activity, resulting in phosphorylation and inactivation of cofilin family proteins. Cofilin phosphorylation inhibits its filamentous actin-severing activity. The sum total of these events is the stabilization of filamentous actin and increased actin-myosin interactions. Additional phosphorylations catalyzed by ROCK promote myosin ATPase activity and tethering of filamentous actin with membrane-bound structural proteins, which additionally contribute to the generation of actin-myosin contractile force. |
| (summation) | [Pathway:419233] Cytoskeletal regulation [Homo sapiens] |
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