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Details on Person Activation of Cdc42

Class:Id	Reaction:418850
_displayName	Activation of Cdc42
_doRelease	TRUE
_timestamp	2010-12-02 14:35:06
authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
catalystActivity	[CatalystActivity:418851] guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:418857] Garapati, P V, 2009-04-27 09:26:20
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
input	[Complex:418830] CDC42:GDP [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol] [Complex:418829] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:418684] Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion [LiteratureReference:418672] The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
modified	[InstanceEdit:422008] Garapati, P V, 2009-05-25 19:36:41 [InstanceEdit:425942] Garapati, P V, 2009-06-09 [InstanceEdit:446620] Garapati, P V, 2009-11-15 [InstanceEdit:448356] Garapati, P V, 2009-11-24 [InstanceEdit:513007] Garapati, P V, 2010-02-16 [InstanceEdit:532573] Garapati, P V, 2010-03-01 [InstanceEdit:763358] Garapati, P V, 2010-05-20 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of Cdc42
output	[Complex:418820] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:418858] RhoGTPase GEF's recruited to DCC [Homo sapiens] [Reaction:373716] DCC interacting NCK-1 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104632] R-HSA-418850.2
summation	[Summation:418711] RhoGEF complexed with Netrin-1-DCC induces guanine nucleotid...
(hasEvent)	[Pathway:418885] DCC mediated attractive signaling [Homo sapiens]
(precedingEvent)	[Reaction:389788] Activation of PAKs by RAC1 and CDC42 [Homo sapiens] [Reaction:418874] Recruitment and activation of N-WASP by Cdc42 [Homo sapiens] [Reaction:8981926] RAC1 and CDC42 activate PAK3 [Homo sapiens] [Reaction:8981931] RAC1 and CDC42 activate PAK2 [Homo sapiens]
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No pathways have been reviewed or authored by Activation of Cdc42 (418850)