Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Co-activation of P2Y1 and P2Y12 is necessary for complete pl...
| Class:Id | Summation:418607 |
|---|---|
| _displayName | Co-activation of P2Y1 and P2Y12 is necessary for complete pl... |
| _timestamp | 2010-06-02 14:34:51 |
| created | [InstanceEdit:418610] Jupe, S, 2009-04-24 10:40:37 |
| literatureReference | [LiteratureReference:418608] The platelet P2 receptors in arterial thrombosis [LiteratureReference:866440] ADP and platelets: the end of the beginning |
| modified | [InstanceEdit:419592] Jupe, S, 2009-05-05 12:21:33 [InstanceEdit:419684] Jupe, S, 2009-05-05 16:41:38 [InstanceEdit:870198] Jupe, S, 2010-06-02 |
| text | Co-activation of P2Y1 and P2Y12 is necessary for complete platelet activation. P2Y1 is coupled to Gq and helps trigger the release of calcium from internal stores, leading to weak and reversible platelet aggregation. P2Y12 is Gi coupled, inhibiting adenylate cyclase, leading to decreased cAMP, a consequent decrease in cAMP-dependent protein kinase activity which increases cytoplasmic [Ca2+], necessary for activation (Woulfe et al. 2001). In activated platelets, P2Y12 signaling is required for the amplification of aggregation induced by all platelet agonists including collagen, thrombin, thromboxane, adrenaline and serotonin. P2Y12 activation causes potentiation of thromboxane generation, secretion leading to irreversible platelet aggregation and thrombus stabilization. |
| (summation) | [Pathway:392170] ADP signalling through P2Y purinoceptor 12 [Homo sapiens] [Pathway:418592] ADP signalling through P2Y purinoceptor 1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Co-activation of P2Y1 and P2Y12 is necessary for complete pl... (418607)
