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Details on Person Within the beta-arrestin-1:Src:ERK complex, activated Src ph...
| Class:Id | Summation:418165 |
|---|---|
| _displayName | Within the beta-arrestin-1:Src:ERK complex, activated Src ph... |
| _timestamp | 2009-04-17 15:57:06 |
| created | [InstanceEdit:418164] Jupe, S, 2009-04-16 14:08:06 |
| literatureReference | [LiteratureReference:418092] Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1 [LiteratureReference:418234] Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase |
| modified | [InstanceEdit:418233] Jupe, S, 2009-04-17 15:57:12 |
| text | Within the beta-arrestin-1:Src:ERK complex, activated Src phosphorylates and activates ERK. ERK activation requires dual Thr and Tyr phosphorylations, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2. Significant ERK activation requires phosphorylation at both sites, with Tyr phosphorylation preceding that of Thr. This reaction is given as a black-box event because the phosphorylation state of ERK on binding to beta-arrestin-1 is unknown. |
| (summation) | [BlackBoxEvent:418163] Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) [Homo sapiens] |
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No pathways have been reviewed or authored by Within the beta-arrestin-1:Src:ERK complex, activated Src ph... (418165)
