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Details on Person Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1

Class:IdLiteratureReference:418092
_displayNameOpposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1
_timestamp2009-04-15 15:05:02
author[Person:418090] Kuo, FT
[Person:418100] Lu, TL
[Person:418098] Fu, HW
created[InstanceEdit:418097] Jupe, S, 2009-04-15 15:04:44
journalCell Signal
pages1914-23
pubMedIdentifier16580177
titleOpposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1
volume18
year2006
(literatureReference)[Summation:418093] Following receptor activation, PAR1 complexes with beta-arre...
[Summation:418157] The activity of Src-kinase is increased when bound to Beta-a...
[Summation:418165] Within the beta-arrestin-1:Src:ERK complex, activated Src ph...
[Summation:418201] Activated PAR1 can induce the formation of signalling comple...
[Reaction:418091] F2R binds ARRB1 [Homo sapiens]
[BlackBoxEvent:418158] SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) [Homo sapiens]
[BlackBoxEvent:418163] Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) [Homo sapiens]
[Reaction:418170] F2R:ARRB1 binds MAPKs, SRC-1 [Homo sapiens]
[Reaction:418172] F2R binds ARRB2 [Homo sapiens]
[Reaction:418176] F2R:ARRB2 binds MAPKs, SRC-1 [Homo sapiens]
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