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Details on Person P2RY12 binds ADP

Class:Id	Reaction:417829
_displayName	P2RY12 binds ADP
_doRelease	TRUE
_timestamp	2018-08-21 09:37:26
authored	[InstanceEdit:418037] Jassal, Bijay, 2009-04-14
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:417833] Jassal, Bijay, 2009-04-14
edited	[InstanceEdit:418037] Jassal, Bijay, 2009-04-14
input	[SimpleEntity:114564] ADP [extracellular region] [EntityWithAccessionedSequence:391959] P2RY12 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:417854] Purification and functional reconstitution of the human P2Y12 receptor [LiteratureReference:417851] Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270 [LiteratureReference:400628] Identification of the platelet ADP receptor targeted by antithrombotic drugs
modified	[InstanceEdit:420852] Jassal, Bijay, 2009-05-14 [InstanceEdit:420853] Jassal, Bijay, 2009-05-14 [InstanceEdit:422124] Jassal, Bijay, 2009-05-26 [InstanceEdit:422382] Jassal, Bijay, 2009-05-29 [InstanceEdit:532503] Jupe, S, 2010-03-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:6789907] Jupe, Steve, 2015-08-06 [InstanceEdit:9611338] Jassal, Bijay, 2018-06-18 [InstanceEdit:9617272] Jassal, Bijay, 2018-08-21 [InstanceEdit:9617273] Jassal, Bijay, 2018-08-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	P2RY12 binds ADP
output	[Complex:417834] P2RY12:ADP [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeRegulation:9611334] Negative regulation by 'P2RY12:P2RY12 antagonists [plasma membrane]'
releaseDate	2009-06-24
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104163] R-HSA-417829.4
summation	[Summation:417832] P2RY12 (Bodor et al. 2003) is found on the surface of blood ...
(hasEvent)	[Pathway:392170] ADP signalling through P2Y purinoceptor 12 [Homo sapiens] [Pathway:417957] P2Y receptors [Homo sapiens]
(precedingEvent)	[Reaction:392187] Activated P2Y purinoceptor 12 binds G-protein Gi [Homo sapiens] [Reaction:749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779264] Update Tracker - [Reaction:417829] P2RY12 binds ADP - v66:[addRegulator] [_UpdateTracker:9784516] Update Tracker - [Reaction:417829] P2RY12 binds ADP - v54:[modifyText]
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