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Details on Person Trafficking of GluR2-containing AMPA receptors to synapse

Class:IdReaction:416985
_displayNameTrafficking of GluR2-containing AMPA receptors to synapse
_doReleaseTRUE
_timestamp2010-12-02 14:41:31
authored[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity[CatalystActivity:416995] ATP hydrolysis activity of NSF [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:416984] Mahajan, SS, 2009-04-07 15:17:07
edited[InstanceEdit:422465] Mahajan, SS, 2009-05-31 11:49:00
input[DefinedSet:399713] Ca impermeable AMPA receptors [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:416989] PICK1 [plasma membrane] [Homo sapiens]
[DefinedSet:416631] GRIP1/GRIP2 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
literatureReference[LiteratureReference:421008] PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
modified[InstanceEdit:417066] Mahajan, SS, 2009-04-07 15:20:32
[InstanceEdit:421014] Mahajan, SS, 2009-05-15 16:16:20
[InstanceEdit:421060] Mahajan, SS, 2009-05-15 16:27:23
[InstanceEdit:425688] Matthews, L, 2009-06-05
[InstanceEdit:425735] Gillespie, ME, 2009-06-05
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTrafficking of GluR2-containing AMPA receptors to synapse
output[DefinedSet:399713] Ca impermeable AMPA receptors [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:416989] PICK1 [plasma membrane] [Homo sapiens]
[DefinedSet:416631] GRIP1/GRIP2 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:8858531] Negative regulation by 'TSPAN7:PICK1 [plasma membrane]'
regulationReference[RegulationReference:9642553] Negative regulation by 'TSPAN7:PICK1 [plasma membrane]' PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2
releaseDate2009-06-24
reviewed[InstanceEdit:421048] Ziff, EB, 2009-05-15 16:23:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105834] R-HSA-416985.5
summation[Summation:421015] Constitutively recycling GluR2 containing AMPA receptors in ...
[Summation:8858525] Tetraspanin 7 (TSPAN7) a member of the tetraspanin superfami...
(hasEvent)[Pathway:416993] Trafficking of GluR2-containing AMPA receptors [Homo sapiens]
(precedingEvent)[Reaction:421007] Endocytosis of Ca impermeable AMPA receptors [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775510] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v78:[addSummation]
[_UpdateTracker:9779621] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v65:[modifyText]
[_UpdateTracker:9783756] Update Tracker - [Reaction:416985] Trafficking of GluR2-containing AMPA receptors to synapse - v56:[addRegulator]
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