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Details on Person Activation of Rho by LARG and PDZ-RhoGEF

Class:Id	Reaction:416588
_displayName	Activation of Rho by LARG and PDZ-RhoGEF
_doRelease	TRUE
_timestamp	2010-12-02 14:41:32
authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
catalystActivity	[CatalystActivity:416599] guanyl-nucleotide exchange factor activity of SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:416590] Garapati, P V, 2009-03-30 15:26:31
edited	[InstanceEdit:399760] Garapati, P V, 2009-03-23 10:00:07
input	[SimpleEntity:29438] GTP [cytosol] [Complex:419164] RhoA,B,C:GDP [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:416578] Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells [LiteratureReference:416551] Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors [LiteratureReference:416592] Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2
modified	[InstanceEdit:416607] Garapati, P V, 2009-03-30 15:34:28 [InstanceEdit:419648] Garapati, P V, 2009-05-05 12:44:47 [InstanceEdit:422116] Garapati, P V, 2009-05-26 10:25:40 [InstanceEdit:422119] Garapati, P V, 2009-05-26 10:52:13 [InstanceEdit:422120] Garapati, P V, 2009-05-26 12:04:08 [InstanceEdit:422121] Garapati, P V, 2009-05-26 12:44:20 [InstanceEdit:422469] Garapati, P V, 2009-05-31 15:11:59 [InstanceEdit:425942] Garapati, P V, 2009-06-09 [InstanceEdit:434620] Matthews, L, 2009-09-02 [InstanceEdit:500188] Garapati, P V, 2010-02-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of Rho by LARG and PDZ-RhoGEF
output	[SimpleEntity:29420] GDP [cytosol] [Complex:419161] RHOA/B/C:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:416594] LARG and PDZ-RhoGEF binds to Plexin-B1 [Homo sapiens] [Reaction:373750] SEMA4D interacts with Plexin-B1:ErbB2 [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105837] R-HSA-416588.2
summation	[Summation:416567] The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 sti...
(hasEvent)	[Pathway:416572] Sema4D induced cell migration and growth-cone collapse [Homo sapiens]
(precedingEvent)	[Reaction:419049] ROCK activation by RHO [Homo sapiens]
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No pathways have been reviewed or authored by Activation of Rho by LARG and PDZ-RhoGEF (416588)