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Details on Person GRK2 sequesters activated Gq
Class:Id Reaction:416516
_displayName GRK2 sequesters activated Gq
_doRelease TRUE
_timestamp 2017-07-11 09:38:32
authored [InstanceEdit:416522] Jupe, S, 2009-03-27 16:14:26
compartment [Compartment:876] plasma membrane
created [InstanceEdit:416512] Jupe, S, 2009-03-27 16:11:13
edited [InstanceEdit:435382] Jupe, S, 2009-09-09
input [Complex:114534] G-protein alpha (q/11): GTP [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:50270] GRK2 [plasma membrane] [Homo sapiens]
literatureReference [LiteratureReference:416514] Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2 [LiteratureReference:416507] Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex [LiteratureReference:8983500] Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq
modified [InstanceEdit:420853] Jassal, Bijay, 2009-05-14 [InstanceEdit:425218] Jupe, S, 2009-06-03 [InstanceEdit:427697] Jupe, S, 2009-06-23 [InstanceEdit:428751] Jupe, S, 2009-07-09 [InstanceEdit:430261] Jupe, S, 2009-08-06 [InstanceEdit:435181] Jupe, S, 2009-09-07 [InstanceEdit:435383] Jupe, S, 2009-09-09 [InstanceEdit:508592] Jupe, S, 2010-02-15 [InstanceEdit:749449] Jupe, S, 2010-05-18 [InstanceEdit:8983501] Varusai, Thawfeek, 2017-03-24 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name GRK2 sequesters activated Gq
output [Complex:416515] G-protein alpha (q):GRK2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate 2009-09-30
reviewed [InstanceEdit:425201] Akkerman, JW, 2009-06-03
reviewStatus [ReviewStatus:9821382] five stars
revised [InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1105447] R-HSA-416516.3
summation [Summation:416505] GRK2 can inhibit GPCR signaling via phosphorylation-independ...
(hasEvent) [Pathway:416476] G alpha (q) signalling events [Homo sapiens]
(inferredFrom) [Reaction:416510] GRK5 sequesters activated Gq [Homo sapiens]
(updatedInstance) [_UpdateTracker:9781082] Update Tracker - [Reaction:416516] GRK2 sequesters activated Gq - v61:[addLiteratureReference] [_UpdateTracker:9790597] Update Tracker - [Reaction:416516] GRK2 sequesters activated Gq - v33:[add_removeInput] [_UpdateTracker:9790832] Update Tracker - [Reaction:416516] GRK2 sequesters activated Gq - v32:[add_removeInput]
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