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Details on Person The N-formyl peptide receptor 2 (FPR2, LXA4 receptor, FPRL1)...

Class:IdSummation:416395
_displayNameThe N-formyl peptide receptor 2 (FPR2, LXA4 receptor, FPRL1)...
_timestamp2017-12-05 11:39:12
created[InstanceEdit:416452] Jassal, Bijay, 2009-03-26
literatureReference[LiteratureReference:444530] Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses
[LiteratureReference:416378] Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
[LiteratureReference:444490] Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
[LiteratureReference:444559] A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor
[LiteratureReference:444525] Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor
modified[InstanceEdit:444492] Jupe, S, 2009-10-23
[InstanceEdit:447082] Jassal, B, 2009-11-20
[InstanceEdit:9032057] Jassal, Bijay, 2017-12-05
textThe N-formyl peptide receptor 2 (FPR2, LXA4 receptor, FPRL1) (Ye et al. 1992, Fiore et al. 1994) has been reported to respond to numerous ligand with a broad range of structural diversity (Migeotte et al. 2006). It was originally identified as a low-affinity receptor for N-formyl-methionyl peptides but has greater affinity for many ligands including lipoxin A4 (Fiore et al. 1994, Migeotte et al. 2006), annexin-1 (Perretti et al. 2002), the truncated chemokine sCKbeta8-1 (Elagoz et al. 2004) and humanin (Ying et al. 2004).
(summation)[Reaction:391913] FPR2 binds FPR2 ligands [Homo sapiens]
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