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Details on Person Phospholipase C activation is the classical signalling route...
| Class:Id | Summation:416368 |
|---|---|
| _displayName | Phospholipase C activation is the classical signalling route... |
| _timestamp | 2009-05-05 16:47:53 |
| created | [InstanceEdit:416367] Jupe, S, 2009-03-26 13:58:47 |
| literatureReference | [LiteratureReference:416365] Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways [LiteratureReference:416366] Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras |
| modified | [InstanceEdit:419686] Jupe, S, 2009-05-05 16:48:57 |
| text | Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778). |
| (summation) | [Reaction:416358] G alpha (q) inhibits PI3K alpha [Homo sapiens] [Complex:398145] G-protein alpha (12/13):LARG [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by Phospholipase C activation is the classical signalling route... (416368)
