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Details on Person UniProt:Q9Z2D6-1 Mecp2
| Class:Id | ReferenceIsoform:416239 |
|---|---|
| _chainChangeLog | chain:1-484 added on Sat February 7 2015 |
| _displayName | UniProt:Q9Z2D6-1 Mecp2 |
| _timestamp | 2026-02-20 21:41:24 |
| chain | chain:1-484 |
| checksum | 62FD228F0118A49F |
| comment | FUNCTION Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).SUBUNIT Interacts with FNBP3 (PubMed:9171351). Interacts with CDKL5 (By similarity). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells (PubMed:17296936). Interacts with NCOR2 (PubMed:23770565). Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1 (PubMed:28348241). Interacts with TBL1X; recruits TBL1X to the heterochromatin foci (By similarity).SUBCELLULAR LOCATION Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.ALTERNATIVE PRODUCTS Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues.MISCELLANEOUS Ten times higher expression levels than isoform A in brain (at protein level). |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Methyl-CpG-binding protein 2 shortName: MeCp-2 protein shortName: MeCp2 |
| geneName | Mecp2 |
| identifier | Q9Z2D6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing DNA-binding Methylation Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Mecp2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MECP2_MOUSE B1AUZ2 B1AUZ3 Q3TYG1 |
| sequenceLength | 484 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q9Z2D6-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:9005845] Mecp2_e2 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9005849] p-T308-Mecp2_e2 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9005868] Mecp2_e2 R306C [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9007017] p-S421-Mecp2_e2 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9022348] p-S80-Mecp2_e2 [nucleoplasm] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:9005846] O-phospho-L-threonine at 308 [ReplacedResidue:9005871] L-arginine 306 replaced with L-cysteine [ReplacedResidue:9005874] L-arginine 306 replaced with L-histidine [ModifiedResidue:9007018] O-phospho-L-serine at 421 [ModifiedResidue:9022344] O-phospho-L-serine at 80 |
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No pathways have been reviewed or authored by UniProt:Q9Z2D6-1 Mecp2 (416239)
