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Details on Person UniProt:Q9Y618 NCOR2

Class:Id	ReferenceGeneProduct:416107
_chainChangeLog	chain:1-2525 added on Fri February 6 2015
_displayName	UniProt:Q9Y618 NCOR2
_timestamp	2026-02-20 21:51:37
chain	chain:1-2514
checksum	70A89C9A19612AAD
comment	FUNCTION Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).FUNCTION Isoform 1 and isoform 4 have different affinities for different nuclear receptors.FUNCTION Isoform 1 and isoform 4 have different affinities for different nuclear receptors.SUBUNIT Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:10809664, PubMed:10944117, PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts (via 1D-myo-inositol 1,4,5,6-tetrakisphosphate) with HDAC3; promoting the histone deacetylase activity of HDAC3 (PubMed:22230954). Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024). Interacts with TBL1Y (PubMed:30341416). Interacts with SANBR (via the BTB domain) (By similarity).SUBCELLULAR LOCATION Ubiquitous (PubMed:10077563). High levels of expression are detected in lung, spleen and brain (PubMed:10077563).INDUCTION Regulated during cell cycle progression.DOMAIN The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).DOMAIN The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.DOMAIN The deacetylase activation domain (DAD) promotes the recruitment and activation of HDAC3 (PubMed:22230954). Inositol tetraphosphate (1D-myo-inositol 1,4,5,6-tetrakisphosphate) acts as an intermolecular glue between HDAC3 and NCOR2 (PubMed:22230954).MISCELLANEOUS Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.SIMILARITY Belongs to the N-CoR nuclear receptor corepressors family.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: fullName evidence="38"Nuclear receptor corepressor 2 shortName evidence="38"N-CoR2 alternativeName: CTG repeat protein 26 alternativeName: SMAP270 alternativeName: fullName evidence="32"Silencing mediator of retinoic acid and thyroid hormone receptor shortName evidence="32"SMRT alternativeName: fullName evidence="36"T3 receptor-associating factor shortName evidence="36"TRAC alternativeName: fullName evidence="36"Thyroid-, retinoic-acid-receptor-associated corepressor
geneName	NCOR2 CTG26
identifier	Q9Y618
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Coiled coil DNA-binding Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	NCOR2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999020] ENSEMBL:ENSG00000196498 NCOR2 [Homo sapiens]
secondaryIdentifier	NCOR2_HUMAN O00613 O15416 O15421 Q13354 Q56D06 Q59GM0 Q9Y5U0
sequenceLength	2514
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:59993] UniProt:Q9Y618-1 NCOR2 [Homo sapiens] [ReferenceIsoform:150904] UniProt:Q9Y618-2 NCOR2 [Homo sapiens] [ReferenceIsoform:424965] UniProt:Q9Y618-4 NCOR2 [Homo sapiens] [ReferenceIsoform:424966] UniProt:Q9Y618-5 NCOR2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:442469] NCOR2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3927904] monoSUMO1-K672-NCOR2 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:3927799] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 672
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No pathways have been reviewed or authored by UniProt:Q9Y618 NCOR2 (416107)