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Details on Person UniProt:Q9Y5S9-1 RBM8A
| Class:Id | ReferenceIsoform:416092 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-174 added on Fri February 6 2015;initiator methionine:1 for 416092 removed on Fri Nov 03 2023;initiator methionine: for 416092 added on Fri Nov 03 2023;initiator methionine: for 416092 removed on Fri Aug 15 2025;initiator methionine:1 for 416092 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9Y5S9-1 RBM8A |
| _timestamp | 2026-02-20 22:59:08 |
| chain | initiator methionine:1 chain:2-174 |
| checksum | 70BBD03CDDFEECFE |
| comment | FUNCTION Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.SUBUNIT Heterodimer with either MAGOH or MAGOHB (PubMed:10662555, PubMed:12730685, PubMed:12781131, PubMed:23917022). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A (PubMed:11707413, PubMed:16170325, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275, PubMed:23917022). Component of the ALYREF/THOC4-EJC-RNA complex; in the complex interacts with EIF4A3 and MAGOH; these interactions are likely specific to RNA-bound EJC (PubMed:16314458, PubMed:37020021). Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs (PubMed:14968132, PubMed:18026120, PubMed:19410547). Part of a complex that contains the EJC core components CASC3, EIF4A3, MAGOH and RBM8A plus proteins involved in nonsense-mediated mRNA decay, such as UPF1, UPF2, UPF3A and UPF3B (PubMed:11546873, PubMed:12718880, PubMed:20479275). Found in a post-splicing complex with NXF1, MAGOH, UPF1, UPF2, UPF3A, UPF3B and RNPS1 (PubMed:11546874). Interacts with DDX39B, MAGOH, DPH1, UPF3B, RNPS1, SRRM1 and ALYREF/THOC4 (PubMed:11013075, PubMed:11118221, PubMed:11707413, PubMed:12944400). Interacts with IPO13; the interaction mediates the nuclear import of the MAGOH-RBM8A heterodimer (PubMed:11447110). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:29301961). Associates with polysomes (PubMed:12121612).SUBCELLULAR LOCATION Nucleocytoplasmic shuttling protein (PubMed:11030346). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (PubMed:19324961).ALTERNATIVE PRODUCTS Ubiquitous.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the RBM8A family.SEQUENCE CAUTION Chimeric cDNA. A chimeric cDNA originating from chromosomes 1 and 5. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: RNA-binding protein 8A alternativeName: Binder of OVCA1-1 shortName: BOV-1 alternativeName: RNA-binding motif protein 8A alternativeName: fullName evidence="37"RNA-binding protein Y14 alternativeName: Ribonucleoprotein RBM8A |
| geneName | RBM8A RBM8 HSPC114 MDS014 |
| identifier | Q9Y5S9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Isopeptide bond mRNA processing mRNA splicing mRNA transport Nonsense-mediated mRNA decay Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Spliceosome Translation regulation Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RBM8A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003758] ENSEMBL:ENSG00000265241 RBM8A [Homo sapiens] |
| secondaryIdentifier | RBM8A_HUMAN B3KQI9 Q6FHD1 Q6IQ40 Q9GZX8 Q9NZI4 |
| sequenceLength | 174 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9Y5S9-1 |
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No pathways have been reviewed or authored by UniProt:Q9Y5S9-1 RBM8A (416092)
