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Details on Person UniProt:Q9ULK4 MED23
| Class:Id | ReferenceGeneProduct:415505 |
|---|---|
| _chainChangeLog | chain:1-1368 added on Sat February 7 2015 |
| _displayName | UniProt:Q9ULK4 MED23 |
| _timestamp | 2024-11-03 19:57:12 |
| chain | chain:1-1368 |
| checksum | 2BEE9FF5E328477D |
| comment | FUNCTION Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.SUBUNIT Interacts with ELK1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated), CTNNB1, and GLI3. Interacts with the adenovirus E1A protein.INTERACTION Experimental confirmation may be lacking for some isoforms.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Mediator complex subunit 23 family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 23 alternativeName: Activator-recruited cofactor 130 kDa component shortName: ARC130 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 3 shortName: CRSP complex subunit 3 alternativeName: Mediator complex subunit 23 alternativeName: Protein sur-2 homolog shortName: hSur-2 alternativeName: Transcriptional coactivator CRSP130 alternativeName: Vitamin D3 receptor-interacting protein complex 130 kDa component shortName: DRIP130 |
| geneName | MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2 |
| identifier | Q9ULK4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Direct protein sequencing Disease variant Intellectual disability Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MED23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992571] ENSEMBL:ENSG00000112282 MED23 [Homo sapiens] |
| secondaryIdentifier | MED23_HUMAN B9TX55 O95403 Q5JWT3 Q5JWT4 Q6P9H6 Q9H0J2 Q9NTT9 Q9NTU0 Q9Y5P7 Q9Y667 |
| sequenceLength | 1368 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:52866] UniProt:Q9ULK4-1 MED23 [Homo sapiens] [ReferenceIsoform:145987] UniProt:Q9ULK4-2 MED23 [Homo sapiens] [ReferenceIsoform:145988] UniProt:Q9ULK4-3 MED23 [Homo sapiens] [ReferenceIsoform:237041] UniProt:Q9ULK4-4 MED23 [Homo sapiens] [ReferenceIsoform:237042] UniProt:Q9ULK4-5 MED23 [Homo sapiens] [ReferenceIsoform:8972935] UniProt:Q9ULK4-6 MED23 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:556823] MED23 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9ULK4 MED23 (415505)
