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Details on Person UniProt:Q9UKJ1 PILRA
| Class:Id | ReferenceGeneProduct:415453 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-303 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UKJ1 PILRA |
| _timestamp | 2024-11-03 19:57:58 |
| chain | signal peptide:1-19 chain:20-303 |
| checksum | 77BD068C63274A40 |
| comment | FUNCTION Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.FUNCTION (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.SUBUNIT Monomer. Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon tyrosine phosphorylation.SUBUNIT (Microbial infection) Interacts with herpes simplex virus 1 glycoprotein B.INTERACTION Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.DOMAIN Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif.PTM According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.PTM Phosphorylated on tyrosine residues. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Paired immunoglobulin-like type 2 receptor alpha alternativeName: Cell surface receptor FDF03 alternativeName: Inhibitory receptor PILR-alpha |
| geneName | PILRA |
| identifier | Q9UKJ1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Glycoprotein Host-virus interaction Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PILRA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992660] ENSEMBL:ENSG00000085514 PILRA [Homo sapiens] |
| secondaryIdentifier | PILRA_HUMAN Q8NHI1 |
| sequenceLength | 303 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:197759] UniProt:Q9UKJ1-3 PILRA [Homo sapiens] [ReferenceIsoform:197765] UniProt:Q9UKJ1-4 PILRA [Homo sapiens] [ReferenceIsoform:197776] UniProt:Q9UKJ1-1 PILRA [Homo sapiens] [ReferenceIsoform:197783] UniProt:Q9UKJ1-2 PILRA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3008978] PILRA [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UKJ1 PILRA (415453)
