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Details on Person UniProt:Q9QYE3-1 Bcl11a
| Class:Id | ReferenceIsoform:415163 |
|---|---|
| _chainChangeLog | chain:1-773 added on Fri February 6 2015;chain:1-773 for 415163 removed on Fri Aug 15 2025;chain:1-835 for 415163 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9QYE3-1 Bcl11a |
| _timestamp | 2025-10-31 18:57:32 |
| chain | chain:1-835 |
| checksum | 84DC5CA0374998D1 |
| comment | FUNCTION Transcription factor (By similarity). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes (By similarity). Involved in brain development (By similarity). May play a role in hematopoiesis (PubMed:10757802). Essential factor in lymphopoiesis, required for B-cell formation in fetal liver (PubMed:12717432). May function as a modulator of the transcriptional repression activity of NR2F2 (PubMed:10744719).SUBUNIT Homotetrameric; self-associates via C2HC-type zinc finger domain (By similarity). Interacts with MTA2, a component of the nucleosome remodeling and deacetylase (NuRD) repressor complex (By similarity). Interacts with NR2F1, PIAS3, NR2F2 and NR2F6 (PubMed:10744719, PubMed:18681895). Interacts with TBR1 (By similarity).SUBCELLULAR LOCATION Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.ALTERNATIVE PRODUCTS Isoforms are expressed in a tissue-specific fashion. Isoforms 1, isoform 2, and isoform 3 are expressed at similar levels in testis, kidney and spleen. Isoform 1 is expressed in the stomach, and isoform 2 is expressed exclusively in the lung. Overexpression following proviral integration in hematopoietic cells results in the generation of myeloid leukemia.DEVELOPMENTAL STAGE Highly expressed in the developing embryo. Expressed in developing brain from 10.5 dpc, with highest expression in the forebrain between 12.5 dpc and 14.5 dpc. Central nervous system expression persists throughout the postnatal period in the cortex, hippocampus, olfactory buld, and, to a lesser extent, in the cerebellum.DOMAIN The N-terminus is involved in protein dimerization and in transactivation of transcription.DOMAIN Zinc finger domains are necessary for sequence-specific binding to DNA.PTM Sumoylated with SUMO1.DISRUPTION PHENOTYPE Germline biallelic loss of Bcl11a leads to perinatal lethality. Bcl11a +/- mice have a significantly decreased brain volume, affecting both gray and white matter. The limbic system (hippocampus and amygdala) is among the brain regions that are more severely affected. Bcl11a +/- mice display normal novelty-seeking behavior but show long-term social memory defects, impaired sociability, and increased physical activity. Bcl11a +/- mice show dynamic postnatal transcriptional dysregulation in the brain.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: BCL11 transcription factor A alternativeName: B-cell CLL/lymphoma 11A alternativeName: B-cell lymphoma/leukemia 11A shortName: BCL-11A alternativeName: COUP-TF-interacting protein 1 alternativeName: Ecotropic viral integration site 9 protein shortName: EVI-9 |
| geneName | Bcl11a Ctip1 Evi9 Kiaa1809 |
| identifier | Q9QYE3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm DNA-binding Isopeptide bond Metal-binding Methylation Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 |
| name | Bcl11a |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BC11A_MOUSE Q5STS9 Q80T89 Q8BLC7 Q8BLR4 Q8BWX3 Q921V4 Q9D0V2 Q9JIT4 Q9JLK8 Q9JLK9 |
| sequenceLength | 835 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q9QYE3-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9QYE3-1 Bcl11a (415163)
