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Details on Person UniProt:Q9NZH6-1 IL37
| Class:Id | ReferenceIsoform:414948 |
|---|---|
| _chainChangeLog | propeptide:1-45 added on Fri February 6 2015;chain:46-218 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NZH6-1 IL37 |
| _timestamp | 2024-11-03 20:19:31 |
| chain | propeptide:1-45 chain:46-218 |
| checksum | 96E089310D2CEA68 |
| comment | FUNCTION Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.SUBUNIT Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).INTERACTION Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380).ALTERNATIVE PRODUCTS In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.INDUCTION Highly induced by bacterial lipopolysaccharides (LPS) and TGFB1, more moderately by IFNG, IL18, IL1B, TNF and the dinucleotide CpG (at protein level). Constitutive expression in bone marrow macrophages is down-regulated in the presence of IL4 and CSF2. Induced by phorbol myristate acetate (PMA) in different cell lines.PTM Proteolytically converted to the mature form by CASP1.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The name IL-HL refers to isoform B containing polymorphisms Val-31 and Ala-42.SIMILARITY Belongs to the IL-1 family.ONLINE INFORMATION Interleukin-1 entry |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Interleukin-37 shortName: IL-37 alternativeName: FIL1 zeta alternativeName: IL-1X alternativeName: Interleukin-1 family member 7 shortName: IL-1F7 alternativeName: Interleukin-1 homolog 4 shortName: IL-1H shortName: IL-1H4 alternativeName: Interleukin-1 zeta shortName: IL-1 zeta alternativeName: Interleukin-1-related protein shortName: IL-1RP1 |
| geneName | IL37 FIL1Z IL1F7 IL1H4 IL1RP1 |
| identifier | Q9NZH6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytokine Cytoplasm Direct protein sequencing Disease variant Nucleus Proteomics identification Reference proteome Secreted |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IL37 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990769] ENSEMBL:ENSG00000125571 IL37 [Homo sapiens] |
| secondaryIdentifier | IL37_HUMAN B5BU97 Q56AP9 Q8TD04 Q8TD05 Q9HBF2 Q9HBF3 Q9UHA6 |
| sequenceLength | 218 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NZH6-1 |
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No pathways have been reviewed or authored by UniProt:Q9NZH6-1 IL37 (414948)
