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Details on Person UniProt:Q9NZ94 NLGN3
| Class:Id | ReferenceGeneProduct:414937 |
|---|---|
| _chainChangeLog | signal peptide:1-37 added on Fri February 6 2015;chain:38-848 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NZ94 NLGN3 |
| _timestamp | 2026-02-20 21:42:06 |
| chain | signal peptide:1-37 chain:38-848 |
| checksum | B3EE2FAB7E427C82 |
| comment | FUNCTION Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).SUBUNIT Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity). Interacts with neurexins NRXN1, NRXN2 and NRXN3 (By similarity). Interaction with neurexins is mediated by heparan sulfate glycan modification on neurexin (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity).INTERACTION Detected at both glutamatergic and GABAergic synapses. Localizes to dendritic membrane.ALTERNATIVE PRODUCTS Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.PTM N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the type-B carboxylesterase/lipase family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Neuroligin-3 alternativeName: Gliotactin homolog |
| geneName | NLGN3 KIAA1480 NL3 |
| identifier | Q9NZ94 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Asperger syndrome Autism Autism spectrum disorder Cell adhesion Cell membrane Cell projection Disease variant Disulfide bond Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Signal Synapse Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NLGN3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989665] ENSEMBL:ENSG00000196338 NLGN3 [Homo sapiens] |
| secondaryIdentifier | NLGN3_HUMAN B2RBK1 D2X2H6 D3DVV0 D3DVV1 Q86V51 Q8NCD0 Q9NZ95 Q9NZ96 Q9NZ97 Q9P248 |
| sequenceLength | 848 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:96404] UniProt:Q9NZ94-1 NLGN3 [Homo sapiens] [ReferenceIsoform:151138] UniProt:Q9NZ94-2 NLGN3 [Homo sapiens] [ReferenceIsoform:8967943] UniProt:Q9NZ94-3 NLGN3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201565] NLGN3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6788644] NLGN3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NZ94 NLGN3 (414937)
