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Details on Person UniProt:Q9NQ66-1 PLCB1
| Class:Id | ReferenceIsoform:414674 |
|---|---|
| _chainChangeLog | chain:1-1216 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NQ66-1 PLCB1 |
| _timestamp | 2024-11-03 20:07:01 |
| chain | chain:1-1216 |
| checksum | 6F4263D1A50C6FD1 |
| comment | FUNCTION Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)COFACTOR Interacts with DGKQ.INTERACTION Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.ALTERNATIVE PRODUCTS Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="16"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 ecNumber evidence="11"3.1.4.11 alternativeName: PLC-154 alternativeName: Phosphoinositide phospholipase C-beta-1 alternativeName: Phospholipase C-I shortName: PLC-I alternativeName: Phospholipase C-beta-1 shortName: PLC-beta-1 |
| geneName | PLCB1 KIAA0581 |
| identifier | Q9NQ66 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Cytoplasm Epilepsy Hydrolase Lipid degradation Lipid metabolism Lipoprotein Membrane Nucleus Palmitate Phosphoprotein Proteomics identification Reference proteome Transducer |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PLCB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992664] ENSEMBL:ENSG00000182621 PLCB1 [Homo sapiens] |
| secondaryIdentifier | PLCB1_HUMAN D3DW12 D3DW13 O60325 Q17RQ6 Q5TFF7 Q5TGC9 Q8IV93 Q9BQW2 Q9H4H2 Q9H8H5 Q9NQ65 Q9NQH9 Q9NTH4 Q9UJP6 Q9UM26 |
| sequenceLength | 1216 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NQ66-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NQ66-1 PLCB1 (414674)
