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Details on Person UniProt:Q99PP7-1 Trim33
| Class:Id | ReferenceIsoform:413302 |
|---|---|
| _chainChangeLog | chain:1-1142 added on Sat February 7 2015 |
| _displayName | UniProt:Q99PP7-1 Trim33 |
| _timestamp | 2023-11-03 18:19:51 |
| chain | chain:1-1142 |
| checksum | D43699AE75F0893F |
| comment | FUNCTION Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade) (By similarity).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Homooligomer and heterooligomer with TRIM24 and TRIM28 family members (By similarity). Interacts with SMAD4 in unstimulated cells (By similarity). Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta (By similarity). Interacts with SMAD2 and SMAD3 (By similarity). Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling (By similarity).INTERACTION In discrete nuclear dots resembling nuclear bodies (PubMed:15314655, PubMed:16751102). Localizes to sites of DNA damage (By similarity).ALTERNATIVE PRODUCTS Ubiquitous with high level in testis.DEVELOPMENTAL STAGE Expressed in round hematopoietic cells in yolk sac blood islands at 8.5 dpc. Expressed uniformly at 10.5 dpc. Expressed in the brain, spinal cord, neuroepithelium and in spinal ganglia at 12.5 dpc. Expressed in brain, spinal cord, developing epithelia of the lung, stomach, intestine, outer region of the developing kidney, liver, brown fat tissue, skeletal muscle, developing craniofacial region, thymus, cochlear and pharyngeal epithelia and olfactory and respiratory epithelia at 16.5 dpc.PTM Sumoylated with SUMO1.SIMILARITY Belongs to the TRIM/RBCC family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: E3 ubiquitin-protein ligase TRIM33 ecNumber: 2.3.2.27 alternativeName: Ectodermin homolog alternativeName: fullName evidence="13"RING-type E3 ubiquitin transferase TRIM33 alternativeName: Transcription intermediary factor 1-gamma shortName: TIF1-gamma alternativeName: Tripartite motif-containing protein 33 |
| geneName | Trim33 Kiaa1113 |
| identifier | Q99PP7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Bromodomain Coiled coil DNA-binding Isopeptide bond Metal-binding Methylation Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Trim33 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TRI33_MOUSE Q6SI71 Q6ZPX5 |
| sequenceLength | 1142 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q99PP7-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q99PP7-1 Trim33 (413302)
