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Details on Person UniProt:Q99704-1 DOK1
| Class:Id | ReferenceIsoform:413166 |
|---|---|
| _chainChangeLog | chain:1-481 added on Fri February 6 2015 |
| _displayName | UniProt:Q99704-1 DOK1 |
| _timestamp | 2024-11-03 19:50:48 |
| chain | chain:1-481 |
| checksum | E9D947831244BA6C |
| comment | FUNCTION DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.SUBUNIT Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. Interacts with SRMS (via the SH2 and SH3 domains).INTERACTION Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.DOMAIN The PTB domain mediates receptor interaction.PTM Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.MISCELLANEOUS Produced by alternative initiation at Met-140 of isoform 1.SIMILARITY Belongs to the DOK family. Type A subfamily. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Docking protein 1 alternativeName: Downstream of tyrosine kinase 1 alternativeName: p62(dok) alternativeName: pp62 |
| geneName | DOK1 |
| identifier | Q99704 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Alternative splicing Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DOK1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990080] ENSEMBL:ENSG00000115325 DOK1 [Homo sapiens] |
| secondaryIdentifier | DOK1_HUMAN O43204 Q53TY2 Q9UHG6 |
| sequenceLength | 481 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q99704-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q99704-1 DOK1 (413166)
