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Details on Person UniProt:Q96RN5 MED15

Class:Id	ReferenceGeneProduct:413072
_chainChangeLog	chain:1-788 added on Fri February 6 2015
_displayName	UniProt:Q96RN5 MED15
_timestamp	2024-11-03 19:37:30
chain	chain:1-788
checksum	BB6AC6C63ED2F97E
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and SREBF2. Interacts with WWTR1. Interacts with TRIM11.INTERACTION Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney.INDUCTION By 12-O-tetradecanoylphorbol-13-acetate (TPA).PTM Ubiquitinated by TRIM11, leading to proteasomal degradation.POLYMORPHISM The poly-Gln region from amino acids 235-262 of PCQAP is polymorphic. There are from 15 to 18 repeats in the Italian population.SIMILARITY Belongs to the Mediator complex subunit 15 family.SEQUENCE CAUTION Several sequencing errors.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: Mediator of RNA polymerase II transcription subunit 15 alternativeName: Activator-recruited cofactor 105 kDa component shortName: ARC105 alternativeName: CTG repeat protein 7a alternativeName: Mediator complex subunit 15 alternativeName: Positive cofactor 2 glutamine/Q-rich-associated protein shortName: PC2 glutamine/Q-rich-associated protein alternativeName: TPA-inducible gene 1 protein shortName: TIG-1 alternativeName: Trinucleotide repeat-containing gene 7 protein
geneName	MED15 ARC105 CTG7A PCQAP TIG1 TNRC7
identifier	Q96RN5
isSequenceChanged	FALSE
keyword	3D-structure Activator Alternative splicing Cytoplasm Direct protein sequencing Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Triplet repeat expansion Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	MED15
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988498] ENSEMBL:ENSG00000099917 MED15 [Homo sapiens]
secondaryIdentifier	MED15_HUMAN D3DX31 D3DX32 O15413 Q6IC31 Q8NF16 Q96CT0 Q96IH7 Q9P1T3
sequenceLength	788
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:61368] UniProt:Q96RN5-1 MED15 [Homo sapiens] [ReferenceIsoform:151857] UniProt:Q96RN5-2 MED15 [Homo sapiens] [ReferenceIsoform:236995] UniProt:Q96RN5-3 MED15 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:556827] MED15 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q96RN5 MED15 (413072)