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Details on Person UniProt:Q96MS0-1 ROBO3
| Class:Id | ReferenceIsoform:412950 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21-1386 added on Sat February 7 2015 |
| _displayName | UniProt:Q96MS0-1 ROBO3 |
| _timestamp | 2024-11-03 20:07:25 |
| chain | signal peptide:1-20 chain:21-1386 |
| checksum | 955A7300A2BDA27F |
| comment | FUNCTION Receptor involved in axon guidance during development (PubMed:15105459). Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (By similarity).SUBUNIT Monomer (PubMed:32198364). Interacts (via Fibronectin type-III 1 domain) with NELL2 (via the EGF domains) with a 3:3 stoichiometry; this interaction promotes oligomerization of ROBO3 resulting in the repulsion of commissural axons in the midline (PubMed:32198364).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the immunoglobulin superfamily. ROBO family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Roundabout homolog 3 alternativeName: Roundabout-like protein 3 |
| geneName | ROBO3 |
| identifier | Q96MS0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chemotaxis Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Membrane Neurogenesis Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ROBO3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995098] ENSEMBL:ENSG00000154134 ROBO3 [Homo sapiens] |
| secondaryIdentifier | ROBO3_HUMAN |
| sequenceLength | 1386 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96MS0-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:426410] ROBO3.1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9010775] p-S1330-ROBO3.1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9011239] p-Y1019-ROBO3.1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9011301] Ub-ROBO3.1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9010772] O-phospho-L-serine at 1330 [ModifiedResidue:9011237] O4'-phospho-L-tyrosine at 1019 [GroupModifiedResidue:9011303] ubiquitinylated lysine (Ub [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q96MS0-1 ROBO3 (412950)
