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Details on Person UniProt:Q96G25 MED8

Class:Id	ReferenceGeneProduct:412772
_chainChangeLog	chain:1-268 added on Fri February 6 2015
_displayName	UniProt:Q96G25 MED8
_timestamp	2024-11-03 20:01:48
chain	chain:1-268
checksum	6C186A4CECD1AFB3
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. May be part of a multisubunit E3 ubiquitin-protein ligase complex with the elongin BC complex (ELOB and ELOC), CUL2 and RBX1.INTERACTION The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].SIMILARITY Belongs to the Mediator complex subunit 8 family.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
description	recommendedName: Mediator of RNA polymerase II transcription subunit 8 alternativeName: Activator-recruited cofactor 32 kDa component shortName: ARC32 alternativeName: Mediator complex subunit 8
geneName	MED8
identifier	Q96G25
isSequenceChanged	FALSE
keyword	3D-structure Activator Alternative splicing Coiled coil Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation pathway
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	MED8
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000687] ENSEMBL:ENSG00000159479 MED8 [Homo sapiens]
secondaryIdentifier	MED8_HUMAN A9IZ91 A9IZ92 Q5JUY8 Q96FQ4
sequenceLength	268
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:95062] UniProt:Q96G25-1 MED8 [Homo sapiens] [ReferenceIsoform:150192] UniProt:Q96G25-2 MED8 [Homo sapiens] [ReferenceIsoform:237100] UniProt:Q96G25-3 MED8 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:556784] MED8 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q96G25 MED8 (412772)