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Details on Person UniProt:Q96CA5-1 BIRC7
| Class:Id | ReferenceIsoform:412679 |
|---|---|
| _chainChangeLog | chain:1-298 added on Fri February 6 2015;chain:53-298 added on Fri February 6 2015 |
| _displayName | UniProt:Q96CA5-1 BIRC7 |
| _timestamp | 2024-11-03 19:59:53 |
| chain | chain:1-298 chain:53-298 |
| checksum | B2EAAEE531BEC101 |
| comment | FUNCTION Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11084335, PubMed:11162435, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045).FUNCTION Blocks staurosporine-induced apoptosis (PubMed:11322947). Promotes natural killer (NK) cell-mediated killing (PubMed:18034418).FUNCTION Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947). Protects against natural killer (NK) cell-mediated killing (PubMed:18034418).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SUBUNIT Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain.INTERACTION Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.ALTERNATIVE PRODUCTS Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.DOMAIN The RING domain is essential for autoubiquitination.PTM Autoubiquitinated and undergoes proteasome-mediated degradation.PTM The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.SIMILARITY Belongs to the IAP family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Baculoviral IAP repeat-containing protein 7 ecNumber evidence="11"2.3.2.27 alternativeName: Kidney inhibitor of apoptosis protein shortName: KIAP alternativeName: Livin alternativeName: Melanoma inhibitor of apoptosis protein shortName: ML-IAP alternativeName: RING finger protein 50 alternativeName: fullName evidence="16"RING-type E3 ubiquitin transferase BIRC7 component recommendedName: Baculoviral IAP repeat-containing protein 7 30kDa subunit shortName: Truncated livin shortName: p30-Livin shortName: tLivin /component |
| geneName | BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 |
| identifier | Q96CA5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Cytoplasm Golgi apparatus Metal-binding Nucleus Protease inhibitor Proteomics identification Reference proteome Thiol protease inhibitor Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | BIRC7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991735] ENSEMBL:ENSG00000101197 BIRC7 [Homo sapiens] |
| secondaryIdentifier | BIRC7_HUMAN Q9BQV0 Q9H2A8 Q9HAP7 |
| sequenceLength | 298 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96CA5-1 |
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No pathways have been reviewed or authored by UniProt:Q96CA5-1 BIRC7 (412679)
